منابع مشابه
Circulating Ang-II, Centrally Generated Ang-II, and Hypertension
Despite enormous therapeutic advancements, the incidence of hypertension continues to rise and remains a medical burden of global proportions. This is likely due, in part, to the complex pathogenesis of hypertension. In addition to pathological processes in peripheral cardiovascular organs, the central nervous system (CNS) has emerged as a major culprit. The renin–angiotensin system (RAS) plays...
متن کاملAng II receptor expression and effect of Ang II receptor blockade in thyrotoxic rat myocardium.
AIM To investigate the relationship between expression of the angiotensin II (Ang II) receptors and thyroid hormones in the myocardium of rats with thyrotoxicosis. MATERIALS AND METHODS Forty-four adult male Sprague-Dawley rats were divided into four groups: control group (saline), losartan group (10 mg/kg), thyrotoxicosis group (0.5 mg/kg L-thyroid hormone sodium) and thyrotoxicosis-plus-los...
متن کاملAng II Accumulation in Rat Renal Endosomes During Ang II-Induced Hypertension
Hypertension induced by long-term infusion of angiotensin II (Ang II) is associated with augmented intrarenal Ang II levels to a greater extent than can be explained on the basis of the circulating Ang II levels. Although part of this augmentation is due to AT1 receptor–dependent internalization, the intracellular compartments involved in this Ang II accumulation remain unknown. In the present ...
متن کاملSensitization of slow pressor angiotensin II (Ang II)-initiated hypertension: induction of sensitization by prior Ang II treatment.
Sensitization involving the central nervous system has been studied in many conditions but has received little attention in investigation of the pathogenesis of hypertension. Our experiments were initiated to determine whether angiotensin II (Ang II)-induced hypertension can be sensitized by prior Ang II treatment and the role of the brain renin-angiotensin-aldosterone system (RAAS) in this pro...
متن کاملReciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats.
Alterations in the balance between ANG II/ACE and ANG 1-7/ACE2 in ANG II-dependent hypertension could reduce the generation of ANG 1-7 and contribute further to increased intrarenal ANG II. Upregulation of collecting duct (CD) renin may lead to increased ANG II formation during ANG II-dependent hypertension, thus contributing to this imbalance. We measured ANG I, ANG II, and ANG 1-7 contents, a...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology and Hypertension
سال: 2011
ISSN: 1062-4821
DOI: 10.1097/mnh.0b013e3283406f57